INTEGRIS Pharma | Φροντίδα Δερματικών Ελκών

Wound

Care

Wound Care

Skin Ulcers

and Wounds

A dermal injury pertains to an area of the skin that displays a pathological protuberance, swelling (edema), ulcer, trauma, or a change in skin color in the affected region.
Skin ulcers comprise a substantial category of skin impairments, classified into chronic and acute types.
The following are included among the acute ulcers:

Burns
Postoperative Trauma/Cut
Amputation
Degloving injury

Venous
	ulcers Venous ulcers typically appear on the inner side of the calf, above the ankle, and predominantly affect individuals with chronic venous insufficiency, at a rate of approximately 80%.¹


Venous
	ulcers Venous ulcers typically appear on the inner side of the calf, above the ankle, and predominantly affect individuals with chronic venous insufficiency, at a rate of approximately 80%.¹ Read More Venous insufficiency leads to prolonged pooling of blood in the veins of the lower extremities. This, in turn, increases pressure on the leg veins and results in dermatological ulcerous conditions. The size of a venous ulcer can range from a few millimeters to several centimeters, and its shape is usually irregular. Venous ulcers significantly impact the quality of life for patients. They need to be addressed in a timely and effective manner because they tend to: Delay healing. Frequently recur. Cause pain, itching, swelling, and inflammation. Pose a high risk of infection. Due to the reduced ability of the immune system to combat the microbial load in the area, they may lead to the growth of microorganisms and the discharge of significant quantities of foul-smelling fluid.

Arterial

ulcers

Arterial ulcers typically appear on the lower part of the shin and foot, primarily on the sole, toes, and pressure points. They are a result of poor arterial circulation and are mainly observed in patients with Peripheral Arterial Disease, Diabetes, and Lower Limb Ischemia.

Diabetic

Ulcers

Today, 1 in 10 people suffer from diabetes, which means 537 million people worldwide⁸. Diabetic patients are at a greater risk of developing complications in their feet, such as Diabetic Peripheral Neuropathy (DPN), which causes a lack of sensation in the feet, and Peripheral Arterial Disease (PAD), the symptoms of which can include non-healing foot ulcers, leading to infections and even amputations⁹.


Diabetic
	Ulcers Today, 1 in 10 people suffer from diabetes, which means 537 million people worldwide8. Diabetic patients are at a greater risk of developing complications in their feet, such as Diabetic Peripheral Neuropathy (DPN), which causes a lack of sensation in the feet, and Peripheral Arterial Disease (PAD), the symptoms of which can include non-healing foot ulcers, leading to infections and even amputations⁹. Read More According to the Guidelines of the International Working Group on the Diabetic Foot, diabetic ulcers develop in 2% of patients annually, and during their lifetime, 19-34% of diabetic patients will develop diabetic foot ulcers. Even after complete healing of the ulcer, the risk of recurrence reaches 40% within one year and 65% within three years¹⁰. Not all diabetes patients are at risk of developing diabetic ulcers. Those at higher risk include patients with Peripheral Arterial Disease, loss of protective sensation due to Diabetic Peripheral Neuropathy, and foot deformities. In these patients, reduced or complete loss of pain, touch, cold, and heat sensation leads to risks, such as injuries from tight shoes or burns due to the loss of heat sensation. Furthermore, due to poor blood circulation in their lower limbs, wound healing is very difficult for them. Patients with a history of foot ulcers and any level of lower limb amputation are also at an increased risk of developing new ulcers^10,12-14. Recognizing at-risk feet, timely medical evaluation, and regular examination of diabetic feet are extremely important in reducing the risk of complications, especially in high-risk patients. It is also important for patients to be educated about proper foot self-care and to wear appropriate footwear.¹⁰

Pressure

ulcers

Pressure ulcers, also known as bedsores, are wounds that develop due to prolonged pressure on soft tissues (skin, fat, muscles) between a bony prominence and an external surface over an extended period of time.

Sources

Ulcers, 2103, http://dx.doi.org/10.1155/2013/413604
G. Casey, “Causes and management of leg and foot ulcers,” Nursing Standard, vol. 18, no. 45, pp. 57–58, 2004.
https://www.nhs.uk/conditions/peripheral-arterial-disease-pad/
Diabetes Spectr. 2008; 21:171–177
Diabetes Care. 2001; 24:860–864
J Am Coll Cardiol. 2006; 47:921–929
Diabet Med. 2009; 26:142–148
https://idf.org/
https://diabetesatlas.org/2022-reports/
https://iwgdfguidelines.org/wp-content/uploads/2019/05/IWGDF-Guidelines-2019.pdf
J Wound Tech 2012;17:14-20
Jeffcoate WJ, Chipchase SY, Ince P, Game FL. Assessing the outcome of the management of diabetic foot ulcers using ulcer-related and person-related measures. Diabetes Care. 2006;29(8):1784-7. https://diabetesjournals.org/care/article/29/8/1784/28622/Assessing-the- Outcome-of-the-Management-of
Prompers L, Schaper N, Apelqvist J, Edmonds M, Jude E, Mauricio D, et al. Prediction of outcome in individuals with diabetic foot ulcers: focus on the differences between individuals with and without peripheral arterial disease. The EURODIALE Study. Diabetologia. 2008;51(5):747-55. https://www.researchgate.net/publication/5555474_Prediction_of_outcome_in_individuals_with_diabetic_foot_ulcers_Focus_on_the_differences_between_individuals_with_and_without_peripheral_arterial_disease_The_EURODIALE_Study
International Diabetes F. Time to Act: diabetes and foot care. Brussels: International Diabetes Federation2005. https://www. worlddiabetesfoundation.org/sites/default/files/Diabetes%20and%20Foot%20care_Time%20to%20act.pdf
https://www.ncbi.nlm.nih.gov/books/NBK553107/
https://www.ncbi.nlm.nih.gov/books/NBK532897/

This information is intended for public awareness purposes only and, under no circumstances, can it replace the advice of a doctor or another qualified healthcare professional.

Therapeutic

Areas

Oncology

Hematology

Rare and Genetic
Metabolic Diseases

Wound

Care

Oncology

Hematology

Rare and Genetic
Metabolic Diseases

Wound

Care

SWITCH THE LANGUAGE